Publications
2023
Li, J-.Y. Lee, Y. Luo. Health benefits of astaxanthin and its encapsulation for improving bioavailability: A review. J Ag Food Res 2023; 14:400685. epub ahead of print on May 12, 2023. 2023. doi.org/10.1016/j.jafr.2023.100685
M. Tillquist, M.Y. Kawaida, A. S. Reiter, B. I. Smith, H. Jang, J-.Y. Lee, E. C. Lee, S. A. Zinn, S. A. Reed, K. E. Govoni. Restricted- and over-feeding during gestation decreases growth of offspring throughout maturity. Transl Anim Sci 2023; 7:txad061. epub ahead of print on May 31, 2023. doi.org/10.1093/tas/txad061
2022
M-.B. Kim, T. X. Pham, M. Vanluling, V. Kostour, H. Kang, O. Corvino, H. Jang, W. Odell, Y-.K. Park. J-.Y. Lee. Nicotinamide riboside supplementation exerts anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice. J Nutr Biochem 2022; (In press). epub ahead of print on May 25, 2022. doi.org/10.1016/j.jnutbio.2022.109058
M-.B. Kim, M. Bae, Y. Lee, H. Kang, S. Hu, T. X. Pham, Y-.K. Park. J-.Y. Lee. Consumption of low dose fucoxanthin does not prevent hepatic and adipose inflammation and fibrosis in mouse models of diet-induced obesity. Nutrients 2022; 14:2280. org/10.3390/nu14112280
G. Mostofa, M. Tran. S. Gilling, G. Lee, O. Fraher, L. Jin, H. Kang, Y-.K. Park, J-.Y. Lee, L. Wang, D-.J. Shin. miR-200c coordinates HNF1 homeobox B and Apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease. J Biol Chem 2022; 298:101966. Epub ahead of print on April 20, 2022. doi.org/10.1016/j.jbc.2022.101966
Bae, M-.B. Kim, J-.Y. Lee. Fucoxanthin attenuates the changes in energy metabolism during the activation of hepatic stellate cells. Nutrients 2022;14:1902. doi.org/10.3390/nu14091902
L. Miller, L. Anto, C. Garcia, M-.B. Kim, A. Jain, A. A. Provatas, J-.Y. Lee, F. C. Nichols, C. N. Blesso. Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis. J Lipid Res 2022; 63: 100192. epub ahead of print on March 9, 2022. doi: 10.1016/j.jlr.2022.100192
Bae, M-.B. Kim, J-.Y. Lee. Astaxanthin attenuates the changes in the expression of microRNAs involved in the activation of hepatic stellate cells. Nutrients 2022; 14:962. doi.org/10.3390/nu14050962
Y. Li, M-.B. Kim, Y.-K. Park, J.-Y. Lee. Fucoxanthin metabolites exert anti-fibrogenic and antioxidant effects in hepatic stellate cells. J Ag Food Res 2022; 6:100245. epub ahead of print on Nov 24, 2021. doi.org/10.1016/j.jafr.2021.100245
H. Kang, M-.B. Kim, Y-.K. Park, J-.Y. Lee. A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD+ metabolism upon alcohol withdrawal. J Nutr Biochem 2022; 99:108852. epub ahead of print on Sept 21, 2021. doi.org/10.1016/j.jnutbio.2021.108852
2021
C. Tan, T. X. Pham, Y. Lee, J-.Y. Lee, M. J. Balunas. Identification of apocarotenoids as chemical markers of anti-inflammatory activity for spirulina supplements. J Agr Food Chem 2021; 69:12674-12685. epub ahead of print on October 21, 2021. doi.org/10.1021/acs.jafc.1c03015
H. Kang, Y. Lee, M-.B. Kim, S. Hu, H. Jang, Y-.K. Park, J-.Y. Lee. The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male mice but not in females with diet-induced nonalcoholic steatohepatitis. J Pathology 2021; 255:319-329. epub ahead of print on July 19, 2021. doi: 10.1002/path.5758
M-.B. Kim, Y. Lee, M. Bae, H. Kang, S. Hu, T. X. Pham, J-.Y. Lee, Y-.K. Park. Sugar kelp (Saccharina latissimi) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced nonalcoholic steatohepatitis. J Nutr Biochem 2021; 97:108799. epub ahead of print on June 10, 2021. doi: 10.1016/j.jnutbio.2021.108799
H. Kang, Y-.K. Park. J-.Y. Lee. Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages. Lab Invest 2021; 101:1225-1237. epub ahead of print on April 12, 2021. doi: 10.1038/s41374-021-00599-1
M-.B. Kim, H. Kang, Y. Li, Y-.K. Park, J-.Y. Lee. Fucoxanthin inhibits lipopolysaccharide-induced inflammation and oxidative stress by activating nuclear factor E2-related factor 2 via the phosphatidylinositol 3-kinase/AKT pathway in macrophages. Eur J Nutr 2021; 60:3315-3324. epub ahead of print on February 17, 2021. doi: 10.1007/s00394-021-02509-z
S-.Y. Yu, M-.B. Kim, Y-.K. Park, M. Bar, H. Kang, S. Hu, T. X. Pham, R. Carpenter, J. Lee, O-.H. Lee, J-.Y. Lee, Y-.C. Kim. Anthocyanin-rich aronia berry extract mitigates high-fat and high-sucrose diet-induced adipose tissue inflammation by inhibiting NF-kB activation in macrophages. J Med Food 2021; 24:586-594. epub ahead of print on March 22, 2021. doi: 10.1089/jmf.2020.0127
C. Caceres, M-.B. Kim, M. Bae, T. X. Pham, Y. Lee, S. Hu, E. O’Neill, B. Kim, Y-.K. Park, J-.Y. Lee. The effect of cranberry consumption on lipid metabolism and inflammation in human apolipoprotein A-I transgenic mice fed a high fat and high cholesterol diet. Br J Nutr 2021; 126:183-190. epub ahead of print on October 16, 2020. doi: 10.1017/S0007114520004080
S. J. Baek, B. Hammock, I. K. Hwang, Q. X. Li, N. Moustaid-Moussa, Y. Park, S. Safe, N. Suh, S. S. Yi, D. C. Zeldin, Q. Zhong, J. A. Bradbury, M. L. Edin, J. P. Graves, H. Y. Jung, Y. H. Jung, M-.B. Kim, W. Kim, J. Lee, H. Li, J-.S. Moon, I. D. Yoo, Y. Yue, J-.Y. Lee, H. J. Han. Natural products in the prevention of metabolic diseases: Lessons learned from the 20th Frontier Scientists Workshop. Nutrients 2021; 13:1881. doi: 10.3390/nu13061881
H. Kang, Y-.K. Park. J-.Y. Lee. Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages. BBA Mol Cell Biol of Lipids 2021; 1866:158838. epub ahead of print on October 13, 2020.
C. Donepudi, Y. Lee, J-.Y. Lee, J. D. Schuetz, J. E. Manautou. Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes. FASEB J 2021; 35:e21304.
2020
H. Kang, Y. Lee, M. Bae, Y-.K. Park, J-.Y. Lee. Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a sirtuin 1-dependent manner. J Nutr Biochem 2020; 85:108477. epub ahead of print on August 12, 2020.
M-.B. Kim, Y. Lee, M. Bae, H. Kang, T.X. Pham, S. Hu, J-.Y. Lee, Y-.K Park. Comprehensive characterization of metabolic, inflammatory and fibrotic changes in a mouse model of non-alcoholic steatohepatitis. J Nutr Biochem 2020; 85:108463. epub ahead of print on July 10, 2020.
Q. Hu, M. Bae, Y-.K. Park, J-.Y. Lee. n-3 PUFA inhibit TGFb1-induced pro-fibrogenic gene expression by ameliorating the repression of PPARg in hepatic stellate cells. J Nutr Biochem 2020; 85;108478. epub ahead of print on June 15, 2020.
M. Bae, Y. Lee, T. X. Pham, Y-.K. Park, S. Hu, J-.Y. Lee. Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells. Life Sci 2020; 256: 117926. epub ahead of print on June 12, 2020.
C. Donepudi, G. J. Smith, O. Aladeloku, Y. Lee, S. J. Toro, M. Phof, A. L. Slitt, J-.Y. Lee, J. D. Schuetz, L. Wang, J. E. Manautou. Lack of multidrug-resistance associated protein 4 worsens partial hepatectomy-induced hepatic steatosis. Toxicol Sci 2020; 175:301-311. epub ahead of print on March 6, 2020.
L. Miller, C. Jiang, G. H. Norris, C. Carcia, S. Seibel, L. Anto, J-.Y. Lee, C. N. Blesso. Cow’s milk polar lipids reduce atherogenic lipoprotein cholesterol, modulate gut microbiota, and attenuate atherosclerosis development in LDL-receptor knockout mice fed a Western-type diet. J Nutr Biochem 2020; 79: 108351. epub ahead of print on Jan 23, 2020.
M. Bae, M-.B. Kim, Y-.K. Park, J-.Y. Lee. Health benefits of fucoxanthin in the prevention of chronic disease. BBA Mol Cell Biol of Lipids 2020; 1865:158618. epub ahead of print on January 10, 2020.
S. Hu, E-.H. Cho, J-.Y. Lee. Histone deacetylase 9: Its role in the pathogenesis of diabetes and other chronic diseases. Diabetes Metab J 2020; 44: 234-244. epub ahead of print on March 24, 2020
Q. Hu, S. Hu, E. Fleming, J-.Y. Lee, Y. Luo. Chitosan-Caseinate-Dextran Ternary Complex Nanoparticles for Potential Oral Delivery of Astaxanthin with Significantly Improved Bioactivity. Int J. Biol Macromole 2020; 151: 747-756.
2019
Q. Hu, J-.Y. Lee, Y. Luo. Nanoparticles targeting hepatic stellate cells for the treatment of liver fibrosis. Engeneered Sci 2019; 6:12-21.
Y. Lee, C. Y. Han, M. Bae, Y-.K. Park, J-.Y. Lee. Egg phospholipids exert inhibitory effect on intestinal cholesterol absorption in mice. Nutr Res Pract 2019; 13:295-301. epub ahead of print on June 20, 2019.
D. Li, C. Rodia, Z. Johnson, M. Bae, A. Muter, A. Heussinger, N. Tambini, A. Longo, H. Dong, J-.Y. Lee, A. B. Kohan. Intestinal basolateral lipid substrate transport (BLST) is linked to chylomicron secretion and is regulated by apoC-III. J Lipid Res 2019; 60:1503-1515.
M. Bae, Y. Lee, Y-.K. Park, D. Shin, P. Joshi, S. Hong, N. Alder, Sung I. Koo, J-.Y. Lee. Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells. J Nutr Biochem 2019; 71:82-89. epub ahead of print on June 20, 2019.
T. X. Pham, M. Bae, M-.B. Kim, Y. Lee, S. Hu, H. Kang, Y-.K. Park. J-.Y. Lee. Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis. BBA Molecular Basis of Disease 2019; 1865:2451-2463. epub ahead of print on June 11, 2019.
Y. Lee, S. Hu, Y-.K. Park, J-.Y. Lee. Protective actions of carotenoids against non-alcoholic fatty acids disease. Prev Nutr Food Sci 2019; 24:103-113.
M. Bae, M-.B. Kim, H. Kang, Y-.K. Park, J-.Y. Lee. Comparison of carotenoids for their anti-fibrogenic effects in hepatic stellate cells. Lipids 2019; 54:401-410. epub ahead of print on May 29, 2019.
M-.B. Kim, M. Bae, S. Hu, H. Kang, Y-.K. Park, J-.Y. Lee. Fucoxanthin exerts anti-fibrogenic effects in hepatic stellate cells. Biochem Biophy Res Comm 2019; 513 (3): 657-662. epub ahead of print on April 11, 2019.
Y . Lee, J-.Y. Lee. Blackcurrant (Ribes nigrum) Extract Exerts an Anti-inflammatory Action by Modulating Macrophage Phenotypes. Nutrients 2019; 11(5);975.
M. White, J-.Y. Lee. The impact of turmeric or its curcumin extract on liver health: A systemic review of clinical trials. Pharm Pract 2019; 17(1):1350.
T. X. Pham, Y. Lee, M. Bae, S. Hu, H. Kang, M-.B. Kim, Y-.K. Park, J-.Y. Lee. Spirulina supplementation in a mouse model of liver fibrosis reduced the pro-inflammatory response of splenocytes. Br J Nutr 2019; 121:748-755. epub ahead of print on February 26, 2019
Y. Lee, T. X. Pham, M. Bae, S. Hu, E. O’Neill, O. K. Chun, M. J. Han, S. I. Koo, Y-.K. Park. J-.Y. Lee. Blackcurrant (Ribes nigrum) prevents obesity-induced non-alcoholic steatohepatitis in mice. Obesity 2019; 27:112-120.
2018
L. Miller, G. H. Norris, C. Jiang, J. Kry, A. Vitols, C. Carcia, Y-.K. Park. J-.Y. Lee, C. N. Blesso. Long-term supplementation of black elderberry improves HDL function, but promote hyperlipidemia with no effect on atherosclerosis development in apolipoprotein E-knockout mice. Mol Nutr Food Res 2018; 62: 1800404. epub ahead of print on September 29, 2018.
Q. Hu, M. Bae, E. Fleming, J-.Y. Lee, Y. Luo. Biocompatible polymeric nanoparticles with exceptional gastrointestinal stability as oral delivery vehicles for lipophilic bioactives. Food Hydrocolloids 2018; 89:386-395.
T. Wang, Q. Hu, J-.Y. Lee, Y. Luo. Solid lipid-polymer hybrid nanoparticles by in-situ conjugation for oral delivery of astaxanthin. J Agr Food Chem 2018; 66:9473-9480. epub ahead of print on August 21, 2018.
C. Farruggia, M-.B. Kim, M. Bae, Y. Lee, T. X. Pham, Y. Yang, M. J. Han, Y-.K. Park, J-.Y. Lee. Astaxanthin exerts anti-inflammatory and antioxidant properties in macrophages in NRF2-dependent and independent manners. J Nutr Biochem 2018; 62:202-209. epub ahead of print on September 19, 2018.
Wu, Y-.K. Park, M. Lin, J-.Y. Lee, L. Wang. Loss of PDK4 switches the hepatic NF-kB/TNF pathway from pro-survival to pro-apoptosis. Hepatology 2018; 68:1111-1124. epub ahead of print on March 30, 2018.
T. Wang, M. Bae, J-.Y. Lee, Y. Luo. Solid lipid-polymer hybrid nanoparticles prepared with natural biomaterials: A new platform for oral delivery of lipophilic bioactives. Food Hydrocolloids 2018; 84:581-592.
T. X. Pham, M. Bae, Y. Lee, Y-.K. Park. J-.Y. Lee. Transcriptional and post-transcriptional repression of histone deacetylases by docosahexaenoic acid in macrophages. J Nutr Biochem 2018; 57:162-169. epub ahead of print on March 10, 2018. (PMID: 29734115)
M. Bae, Y-.K. Park, J-.Y. Lee. Food components with antifibrotic activity and implications in prevention of liver disease. J Nutr Biochem 2018; 55:1-11. Epub ahead of print on November 16, 2017. (PMID: 29268106)
B. Kim, M. Bae, Y-.K. Park, H. Ma, T. Yuan, N. Seeram, J-.Y. Lee. Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells. Eur J Nutr 2018; 57:405-415. Epub ahead of print on July 17, 2017. (PMID: 28718016)
2017
T. X. Pham, J-.Y. Lee. Epigenetic regulation of adipokines. Int J Mol Sci 2017; 18:1740; doi:10.3390/ijms18081740.
T. X. Pham, Y-.K. Park, M. Bae, J-.Y. Lee. The potential role of an endotoxin-like mechanism for the anti-inflammatory effect of Spirulina platensis in macrophages: Insight into energy phenotype. J Med Food 2017; 20: 201-210. Epub ahead of print on January 25, 2017. (PMID: 28121488).
B. Kim, C. Farruggia, C. S. Ku, T. X. Pham, Y. Yang, M. Bae, Casey J. Wegner, N. J. Farrell, E. Harness, Y-.K. Park, Sung I. Koo, J-.Y. Lee. Astaxanthin inhibited inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. J Nutr Biochem 2017; 43:27-35. epub ahead of print on March 2, 2016. (PMID: 28193580)
Xie, T. M. Vance, B. Kim, S. Lee, C. Caceres, Y. Wang, J-.Y. Lee, O. K. Chun, B. W. Bolling. Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterol in former smokers without lowering biomarkers of inflammation and oxidative stress: a randomized trial. Nutr Res 2017; 37:67-77. (PMID: 28215316)
Y. Yang, M. Bae, Y-.K. Park, Y. Lee, T. X. Pham, S. Rudraiah, J. Manautou, S. I. Koo, J-.Y. Lee. Histone deacetylase 9 plays a role in the anti-fibrogenic effect of astaxanthin in hepatic stellate cells. J Nutr Biochem 2017; 40: 172-177. epub ahead of print on Nov 12, 2016. (PMID: 27915160).
2016
M. Pillai, N. H. Sereda, M. L. Hoffman, E. V. Valley, T. D. Crenshaw, Y-.K. Park, J-.Y. Lee, S. A. Zinn, K. E. Govoni. The effect of poor maternal nutrition during gestation on bone development and mesenchymal stem cell activity in offspring. PlosOne 2016; 11:e0168382. (PMID: 27942040)
B. Kim, S. Lee, Y-.K. Park, C. S. Ku, T. X. Pham, C. J. Wegner, Y. Yang, S. I. Koo, O. K. Chun, J-.Y. Lee. Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice. Nutr Res Pract 2016; 10:494-500. (PMID: 27698956).
T. X. Pham, Y-.K. Park, J-.Y. Lee. Anti-inflammatory effects of Spirulina platensis extract via the modulation of histone deacetylases. Nutrients 2016; 8:E381. Epub ahead of print on June 21, 2016. (PMID: 27338466).
T. X. Pham, J-.Y. Lee. Anti-inflammatory effect of Spirulina platensis in macrophages is beneficial for adipocyte differentiation and maturation by inhibiting Nuclear factor-kB pathway in 3T3-L1 adipocytes. J Med Food 2016; 19:535-542. epub ahead of print on May 20, 2016. (PMID: 27206252)
Patel, A. Akalkotkar, J. J. Bivona III, J-.Y. Lee, Y-.K. Park, M. Yu, S. Colpitts, M. Vajdy. Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice through induction of early interleukin-15 but not interleukin-1b responses. Immunology 2016; 148:352-362. epub ahead of print on May 2, 2016. (PMID: 27135790)
Surendran-Nair, A. Kollanoor-Johny, S. Ananda-Baskaran, C. Norris, J-.Y. Lee, K. Venkitanarayanan. Selenium reduces enterohemorrhagic Escherichia coli O157:H7 verotoxin production and globotriaosylceramide receptor expression on host cells. Future Microbiol 2016; 11:745-756. epub ahead of print on May 18, 2016. (PMID: 27191971)
Xie, S. Lee, T. M. Vance, Y. Wang, B. Kim, J-.Y. Lee, O. K. Chun, B. W. Bolling. Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract. Food Chem 2016; 211:860-868. (PMID: 27283706)
Y. Yang, M. Bae, B. Kim, Y-.K. Park, S. I. Koo, J-.Y. Lee. Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. J Nutr Biochem 2016; 29:21-26. epub ahead of print on Nov 24, 2015. (PMID: 26895661)
E. Dugan, D. Aguilar, Y-.K. Park, J-.Y. Lee, M-L. Fernandez. Dietary consumption lowers systemic inflammation and liver enzymes in typically low-dairy consumers with clinical characteristics of metabolic syndrome. J Am Coll Nutr 2016; 35:255-261. epub ahead of print on Nov 23, 2015. (PMID: 26595359)
Karim., K. Menzies, D. Ryu, C. J. Wegner, X. Wang, E. R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y-.K. Park, P. Alessandra, T. X. Pham, Y. Yang, C. S. Ku, S. I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A. A. Sauve, J-.Y. Lee*, J. Auwerx. Eliciting the mitochondrial unfolded protein response via NAD+ repletion prevents fatty liver disease. Hepatology 2016; 63:1190-1204. epub ahead of print on Sept 25, 2015. (PMID: 26404765) * Shared corresponding authorship.
2015
Lee, B. Kim, S. D. Y, T. Vance, J.S Lee, J-.Y. Lee, S. I. Koo, D.O. Kim, M. H. Drissi, O. K. Chun. Relationship between oxidative stress and bone mass in obesity and effects of berry supplementation on bone remodeling in obese male mice: an exploratory study. J Med Foods 2015; 18:476-482. epub ahead of print on Sept 8, 2014. (PMID: 25198411)
S. Ku, B. Kim, T. X. Pham, Y. Yang, Y-.K. Park, C. L. Weller, T. Carr, J-.Y. Lee. Hypolipidemic effect of a blue-green alga (Nostoc commune) is attributed to its nonlipid fraction by decreasing intestinal cholesterol absorption in C57BL/6J mice. J Med Food 2015; 18:1214-1222. epub ahead of print on July 10, 2015. (PMID: 26161942)
S. Ku, B. Kim, T. X. Pham, Y. Yang, C. J. Wegner, Y-.K. Park, M. Balunas, J-.Y. Lee. Blue-green algae inhibit the development of atherosclerotic lesions in apolipoprotein E knockout mice. J Med Food 2015; 18:1299-1306. epub ahead of print on Nov 13, 2015. (PMID: 26566121)
M-Y. Chung, E. Mah, C. Masterjohn, S. K. Noh, H. J. Park, R. M, Clark, Y-.K. Park, J-.Y. Lee, R. S. Bruno. Green tea lowers hepatic COX-2 and prostaglandin E2 in rats with dietary fat-induced nonalcoholic steatohepatitis. J Med Food 2015; 18:648-655. epub ahead of print on Dec 2, 2014. (PMID: 25453513)
Benn, B. Kim, Y-.K. Park, Y. Yang, T. X. Pham, C.S. Ku, C. Farruggia, E. Harness J. A. Smyth, J-.Y. Lee. Polyphenol-rich blackcurrant extract exerts hypocholesterolemic and hypoglycemic effects in mice fed a diet containing high fat and cholesterol. Br J Nutr 2015: 113:1697-1703. (PMID: 25899149)
Yang, B. Kim, Y-.K. Park, S. I. Koo, J-.Y. Lee. Astaxanthin prevents transforming growth factor b1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochimica Biophysica Acta 2015; 1850:178-185. (PMID: 25450180)
2014
Yang, T. X. Pham, C. J. Wegner, B. Kim, C. S. Ku, Y-.K. Park, J-.Y. Lee. Astaxanthin lowered plasma triglyceride and increased hepatic antioxidant gene expression in diet-induced obesity mice. Br J Nutr 2014; 112:1797-1804. (PMID: 25328157)
Benn, B. Kim, Y-.K. Park, C. J. Wegner, E. Harness, T-G. Nam, D-O. Kim, J. S. Lee, J-.Y. Lee. Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obesity mice. J Nutr Biochem 2014; 25:1019-1025. (PMID: 25034502)
Sittiwong, D. K. Zinnel, R. J. Fenton, D. Marshall, C. F. Story, B. Kim, J-.Y. Lee, R. Powers, R. G. Barletta, P. H. Dussault. Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberculosis. ChemMedChem 2014; 9:1838-1849. (PMID: 24902951)
J. Andersen, J-.Y. Lee, C. N. Blesso, T. P. Carr, M-L. Fernandez. Egg intake during carbohydrate restriction alters peripheral blood mononuclear cell inflammation and cholesterol homeostasis in metabolic syndrome. Nutrients 2014; 6:2650-2667. (PMID: 25045936)
Yang, Y-.K. Park, B. Kim, J-.Y. Lee. Effects of long-term supplementation of blue-green algae on lipid metabolism in C57BL/6J mice. J Nutr Health and Food Sci 2014; 2:1-6. (PMID: 25614902)
Lee, B. Kim, Y. Yang, T. X. Pham, Y-.K. Park, J. Manatou, S. I. Koo, O. K. Chun, J-.Y. Lee. Berry anthocyanins suppress the expression and secretion of pro-inflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kB independent of NRF2-mediated mechanism. J Nutr Biochem 2014; 25:404-411. (PMID: 24565673)
2013
Masterjohn, Y-.K. Park, J-.Y. Lee, S. K. Noh, R. S. Bruno. Dietary fructose feeding increases adipose methylglyoxal accumulation in association with low expression and activity of glyoxalase-2. Nutrients 2013; 5:3311-3328. (PMID: 23966111)
Yang, B. Kim, J-.Y. Lee. Astaxanthin: structure, metabolism, and health benefits. J Hum Nutr Food Sci 2013; 1:1003 (1-11).
Masterjohn, E. Mah, Y-.K. Park, R. Pei, J-.Y. Lee, J. E. Manatou, R. S. Bruno. Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate. Expt Biol Med 2013; 238:360-369. (PMID: 23760001)
J. Andersen, C. N. Blesso, J-.Y. Lee, J. Barona, D. Shah, M. J. Thomas, M. L. Fernandez. Egg consumption during carbohydrate restriction modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome. Lipids 2013; 48:557-567. (PMID: 23494579)
Kim, Y-.K. Park, C. J. Wegner, B. W. Bolling, J-.Y. Lee. Polyphenol-rich chokeberry extract regulates the expression of genes for lipogenesis and cholesterol transport in Caco-2 cells. J Nutr Biochem 2013; 24:1564-1570. (PMID: 23517916)
Kim, C. S. Ku, T. X. Pham, Y-.K. Park, D. A. Martin, L. Xie, J-.Y. Lee, B. W. Bolling. Aronia melanocarpa (chokeberry) polyphenol rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutr Res 2013; 33:406-413. (PMID: 23684442)
S. Ku, Y. Yang, Y-.K. Park, J-.Y. Lee. Health Benefits of blue-green algae: Prevention of cardiovascular disease and nonalcoholic fatty liver disease. J Med Food 2013; 16:103-111. (PMID: 23402636)
S. Ku, T. X. Pham, Y-.K. Park, B. Kim, M. Shin, I. Kang, J-.Y. Lee. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-kB pathway in macrophages and splenocytes. Biochimica Biophysica Acta 2013; 1830:2981-2988. (PMID: 23357040)
J. Wegner, B. Kim, J-.Y. Lee. Trust your gut: Galvanizing nutritional interest in intestinal cholesterol metabolism for protection against cardiovascular diseases. Nutrients 2013; 5: 208-222. (PMID: 23325147)
2012
X. Pham, J-.Y. Lee. Dietary regulation of histone acetylase and deacetylase for the prevention of metabolic diseases. Nutrients 2012; 4:1868-1886. (PMID: 23363995)
Barona, C. N. Blesso, C. J. Andersen, Y-.K. Park, J-.Y. Lee, M-L. Fernandez. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 2012; 4:1945-1957. (PMID: 23222963)
Y-.K. Park, T. X. Pham, J-.Y. Lee. Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages. Inflamm Res 2012; 61:465-472. (PMID: 22240665)
S. Ku, Y-.K. Park, S. L. Coleman, J-.Y. Lee. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. J Nutr Biochem 2012; 23: 1271-1276. (PMID: 22209005)
J-.Y. Lee, Y-.K. Park, S. I. Koo. ATP binding cassette transporter A-I and HDL metabolism: Effects of fatty acids. J Nutr Biochem 2012; 23:1-7. (PMID: 21684139)
E. Kim, R. M. Clark, Y-.K. Park, J-.Y. Lee, M. L. Fernandez. Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet. Nutr Res Pract 2012; 6:113-119. (PMID: 22586499)
H. J. Park, J-.Y. Lee, M.Y. Chung, Y-.K. Park, A. Bower, S. I. Koo, C. Giardina, R. S. Bruno. Green tea extract suppressed NFkB activation and inflammatory responses in a diet-induced obese rats with nonalcoholic steatohepatitis. J Nutr 2012; 142:57-63. (PMID: 22157544)
2011
J. J. Jones, Y-.K. Park, J-.Y. Lee, R. H. Lerman, M. L. Fernandez. A Mediterranean-style, low-glycemic-load, diet reduces the expression of HMG-CoA reductase in mononuclear cells and correlated with decreases in insulin in women with metabolic syndromes. Nutr Res 2011; 31:659-664. (PMID: 22024489)
Y. Yang, J. M. Seo, A. Nguyen, T. X. Pham, H. J. Park, Y-.K. Park, R. S. Bruno, J-.Y. Lee. Astaxanthin from Haematococcus pluvialis lowered plasma lipid concentrations and increased antioxidant defense in apolipoprotein E knockout mice. J Nutr 2011; 141:1611-1617. (PMID: 21734060)
L. Coleman, Y-.K. Park, J-.Y. Lee. Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. Eur J Nutr 2011; 50:323-330. (PMID: 21046125)
M. Seo, J-.Y. Lee, G. E. Ji, J. C. You. Down-regulation of ATP-binding cassette transporter G1 expression by unmethylated CpG oligodeoxynucleotides (CpG ODNs) in RAW 264.7 macrophages. Expt Mol Med 2011; 43:510-516. (PMID: 21737995)
J. Ehlers, S. M. Larson, H. E. Rasmussen, Y-.K. Park, J-.Y. Lee. High-density lipoprotein metabolism in human apolipoprotein B transgenic/brown adipose tissue deficient mice, a model of obesity-induced hyperinsulinemia. Appl Physiol Nutr Metab 2011; 36:313-322. (PMID: 21574779)
Y. Yang, Y-.K. Park, J-.Y. Lee. In vitro and in vivo safety assessment of edible blue green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis. Food Chem Toxicol 2011; 49:1560-1564. (PMID: 21473896)
S. Ku, H. E. Rasmussen, Y-.K. Park, E. D. Jesch, J-.Y. Lee. Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. Nutr Res 2011; 31:278-285. (PMID: 21530801)
J. Park, D. A. DiNatale, M-Y. Chung, Y-.K. Park, J-.Y. Lee, S. I. Koo, M. O’Connor, J. E. Manautou, R. S. Bruno. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem 2011; 22:151-159. (PMID: 20655714)
L. Schlegel, R. Zbasnik, B. H. Lee, T. P. Carr, J-.Y. Lee, C. L. Weller, S. L. Cuppett. Characterization of potential health promoting lipids in the co-products of de-flossed milkweed. J Food Chemistry 2010; 126:15-20.
D. Jesch, J. M. Seo, T. P. Carr, J-.Y. Lee. Sitosterol reduces mRNA and protein expression levels of Niemann-Pick C1-Like 1 (NPC1L1) in FHs 74 Int cells. Nutr Res 2009; 29: 859-866. (PMID: 19963159)
T. Hoi, C. L. Weller, V. L. Schlegel, S. L. Cuppet, J-.Y. Lee, T. P. Carr. Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters. J Funct Food 2009; 1: 381-386.
E. Rasmussen, I. Martinez, J-.Y. Lee, J. Walter. Alteration of the murine gastrointestinal microbiota by edible blue-green algae. J Appl Microbiol 2009; 107: 1108-1118. (PMID: 19486425)
E. Rasmussen, K. R. Blobaum, E. D. Jesch, C. S. Ku, Y-.K. Park, F. Lu, T. P. Carr, J-.Y. Lee. Hypocholesterolemic effect of Nostoc commune var sphaeroides Kützing, an edible blue-green alga. Eur J Nutr 2009; 48:387-394. (PMID: 19404563)
Shrestha, S. J. Ehlers, J-.Y. Lee, M-L. Fernandez, S. I. Koo. Dietary green tea extract lowers plasma and hepatic triglyceride and decreases the expression of SREBP-1c mRNA and its responsive genes in fructose-fed ovariectomized rats. J Nutr 2009; 139:640-645. (PMID: 19193814)
Mulya, J-.Y. Lee, A. K. Gebre, E. Y. Boudyguina, S-K. Chung, T. L. Smith, P. L. Colvin, X. C. Jiang, J. S. Parks. Initial Interaction of ApoA-I with ATP Binding Cassette Transporter A1 (ABCA1) Impacts in vivo metabolic fate of nascent HDL. J Lipid Res 2008; 49:2390-2401. (PMID: 18583707)
Zhu, J-.Y. Lee, J. M. Timmins, J. M. Brown, E. Y. Boudyguina, A. Mulya, A. K. Gebre, M. C. Willingham, E. M. Hiltbold, N. Mishra, N. Maeda, J. S. Parks. Increased cellular free cholesterol in macrophage-specific Abca1 knockout mice enhances pro-inflammatory response of macrophages. J Biol Chem 2008; 283:22930-22941. (PMID: 18552351)
E. Rasmussen, K. R. Blobaum, Y-.K. Park, S. J. Ehlers, F. Lu, J-.Y. Lee. Lipid extract of Nostoc commune var. sphaeroides Kützing, a blue-green alga, inhibits the activation of sterol regulatory element binding proteins in HepG2 cells. J Nutr 2008; 138:476-481. (PMID: 18287352)
Y-.K. Park, H. E. Rasmussen, S. J. Ehlers, K. R. Blobaum, F. Lu, V. L. Schlegal, T. P. Carr, J-.Y. Lee. Repression of proinflammatory gene expression by lipid extract of Nostoc commune var sphaeroides Kützing, a blue-green alga, via inhibition of nuclear factor-κB in RAW 264.7 macrophages. Nutr Res 2008; 28:83-91. (PMID: 19083393)
Young-Nam Kim, J-.Y. Lee, J. A. Driskell. Marginal folate inadequacy observed in a group of young children in Kwangju, Korea. Nutr Res and Practice 2007; 2:120-125. (PMID: 20535397)
Mulya, J-.Y. Lee, A. K. Gebre, M. Thomas, P. L. Colvin, J. S. Parks. Minimal lipidation of pre-b HDL by ABCA1 results in reduced activity to interact with ABCA1. Arterio Thromb Vasc Biol 2007; 27:1828-1836. (PMID: 17510466)
J-.Y. Lee, R. Badeau, A. Mulya, E. Boudyguina, A. K. Gebre, T. L. Smith, J. S. Parks. Functional lecithin:cholesterol acyltransferase (LCAT) deficiency in human apolipoprotein A-I transgenic scavenger receptor class B, type I knockout mice. J Lipid Res 2007; 48:1052-1061. (PMID: 17272829)
J-.Y. Lee, J. M. Timmins, A. Mulya, T. L. Smith, Y. Zhu, E. M. Rubin, P. L. Colvin, J. S. Parks. Plasma HDL in human apoA-I transgenic-Abca1 knockout mice undergo normal intravascular remodeling but are hypercatabolized by the kidney. J Lipid Res 2005; 46:2233-2245. (PMID: 16024913)
M. Timmins, J-.Y. Lee, E. Boudyguina, K. Kluckman, L. R. Brunham, A. Mulya, A. K. Gebre, J. Coutinho, P. L. Colvin, T. L. Smith, M. R. Hayden, N. Maeda, J. S. Parks. Targeted inactivation of hepatic ABCA1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apolipoprotein A-I. J Clin Invest 2005; 115:1333-1342. (PMID: 15841208)
J-.Y. Lee, T. P. Carr. Dietary fatty acids regulate the expression of ABCA5 and ABCG8 in hamsters. Nutr Res 2005; 25:167-175.
J-.Y. Lee, J. S. Parks. ATP-binding cassette AI (ABCA1) and its role in HDL formation. Curr Opin Lipidol 2005; 16:19-25. (PMID: 15650559)
J-.Y. Lee, T. P. Carr. Dietary fatty acids regulate acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase in hamsters. J Nutr 2004; 134:3239-3244. (PMID: 15570019)
J-.Y. Lee, L. Lanningham-Foster, E. Boudyguina, T. Smith, E. R. Young, P. Colvin, M. Thomas, J. S. Parks. 2004. Pre-beta high density lipoprotein has two metabolic fates in human apolipoprotein A-I transgenic mice. J Lipid Res 2004; 45:716-728. (PMID: 14729861)
J-.Y. Lee, N. M. Lewis, S. E. Scheideler, T. P. Carr. Consumption of omega-3 fatty acid-enriched eggs and serum lipids in humans. J Nutraceuticals Funct Med Foods 2003; 4:3-13.
L. Cowles, J-.Y. Lee, D. D. Gallaher, C. L. Stuefer-Powell, T. P. Carr. Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. J Nutr 2002; 132:3119-3122. (PMID: 12368404)
P. Carr, G. Cai, J-.Y. Lee, C. L. Schneider. Cholesteryl ester enrichment of plasma low- density lipoprotein in hamsters fed cereal-based diets containing cholesterol. Proc Soc Exp Biol Med 2000; 233:96-101. (PMID: 10632967)
J-.Y. Lee, S. J. Koo. Effect of the addition of dietary fiber on the quality of Julpyun. J Kor Soc Food Sci 1994; 10(3):267-276.